Article
Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region.
Nature communications - 21 Oct 2021
Aneas Ivy, Decker Donna C, Howard Chanie L, Sobreira Débora R, Sakabe Noboru J, Blaine Kelly M, Stein Michelle M, Hrusch Cara L, Montefiori Lindsey E, Tena Juan, Magnaye Kevin M, Clay Selene M, Gern James E, Jackson Daniel J, Altman Matthew C, Naureckas Edward T, Hogarth Douglas K, White Steven R, Gomez-Skarmeta Jose Luis, Schoetler Nathan, Ober Carole, Sperling Anne I, Nóbrega Marcelo A
Abstract excerpt
Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region within the GWAS-defined segment that acts as an enhancer-blocking element in vivo and in vitro. Chromatin conformation capture showed that this 5 kb region loops to the IL33 promoter, potentially regulating its expression. We show that the asthma-associated...
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