Article
An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression.
Human molecular genetics - 1 Dec 2009
Kiesler Patricia, Shakya Arvind, Tantin Dean, Vercelli Donata
Abstract excerpt
IL-13 is a central effector of Th2-mediated allergic inflammation and is critical for the induction of IgE synthesis. Common IL13 variants are associated with allergy phenotypes in populations of distinct ethnic background. We recently demonstrated that IL13 expression by human CD4+ T cells is paralleled by extensive IL13 locus remodeling, which results in the appearance of multiple DNase I hypersensitive sites....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.