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Article

Asthma-associated variants induce <i>IL33</i> differential expression through a novel regulatory region

2020-09-11

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region within the GWAS-defined segment that acts as a strong regulatory element in vivo and in vitro. Chromatin conformation capture showed that this 5 kb region loops to the IL33 promoter, potentially regulating its expression. Supporting th...

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Literature Corpus work
910fdb6e-f350-5a82-8797-989de0a3c4f2
DOI
10.1101/2020.09.09.290098
Open publication

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Asthma-associated variants induce <i>IL33</i> differential expression through a novel regulatory regionDOI 10.1101/2020.09.09.290098
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