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Article

Targeted epigenome sequencing of eosinophils reveals CpG sites and regulatory variants associated with asthma.

Genomics - 1 May 2026

Dionne-Gagné Rébecca, Madore Anne-Marie, Boucher-Lafleur Anne-Marie, Pastinen Tomi, Laprise Catherine

Abstract excerpt

Eosinophils are pro-inflammatory cells that play a central role in asthmatic inflammation. However, few studies have examined their methylation profiles in asthma, all relying on microarray-based approaches. Here, an epigenome-wide association study in 183 purified eosinophil samples from the Saguenay-Lac-Saint-Jean asthma family cohort was performed using a custom sequencing panel targeting 4,609,564 CpGs in...

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Share to Asthma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epigenesis, Genetic

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Share to Genome-Wide Association Study

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Source

Identifiers

PMID: 41856296
DOI: 10.1016/j.ygeno.2026.111235

Genes

EFNA5
GNAQ
LIMK1
MAEA
SLC9A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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