Article
Phenotypic and functional translation of IL33 genetics in asthma.
The Journal of allergy and clinical immunology - 1 Jan 2021
Ketelaar Maria E, Portelli Michael A, Dijk F Nicole, Shrine Nick, Faiz Alen, Vermeulen Cornelis J, Xu Cheng J, Hankinson Jenny, Bhaker Sangita, Henry Amanda P, Billington Charlote K, Shaw Dominick E, Johnson Simon R, Benest Andrew V, Pang Vincent, Bates David O, Pogson Z E K, Fogarty Andrew, McKeever Tricia M, Singapuri Amisha, Heaney Liam G, Mansur Adel H, Chaudhuri Rekha, Thomson Neil C, Holloway John W, Lockett Gabrielle A, Howarth Peter H, Niven Robert, Simpson Angela, Tobin Martin D, Hall Ian P, Wain Louise V, Blakey John D, Brightling Christopher E, Obeidat Ma'en, Sin Don D, Nickle David C, Bossé Yohan, Vonk Judith M, van den Berge Maarten, Koppelman Gerard H, Sayers Ian, Nawijn Martijn C
Abstract excerpt
BACKGROUND: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevated in sputum and bronchial biopsies of patients with asthma. The functional consequences of IL33 asthma SNPs remain unknown. OBJECTIVE: This study sought to determine whether...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.