Article

Pharmacological CDK4/6 inhibition unravels a p53-induced secretory phenotype in senescent cells

2020-06-05

Abstract excerpt

Cellular senescence is a state of stable growth arrest that acts as a tumor suppressive mechanism. Several anti-cancer interventions function partly by inducing malignant cells into senescence. However, because of systemic administration and lack of specificity, anti-cancer treatments are associated with premature senescence of various non-malignant cells. Therapy-induced non-malignant senescent cells can have pro...

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Literature Corpus work: bb6f4ade-5ac4-5e56-8324-4fede160242d
DOI: 10.1101/2020.06.05.135715

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