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Article

Senescent Cells in Cancer Therapy: Friends or Foes?

29 May 2020

Abstract excerpt

Several cancer interventions induce DNA damage and promote senescence in cancer and nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors collectively termed the senescence-associated secretory phenotype (SASP). SASP factors are able to potentiate various aspects of tumorigenesis, including proliferation, metastasis, and immunosuppression. Moreover, the accumulation and persistence...

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PMID: 32482536
DOI: 10.1016/j.trecan.2020.05.004

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