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Article

The senescence-associated secretory phenotype and its physiological and pathological implications.

Nature reviews. Molecular cell biology - 1 Dec 2024

Wang Boshi, Han Jin, Elisseeff Jennifer H, Demaria Marco

Abstract excerpt

Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations, chronic DNA damage responses, and a hypersecretory state known as the senescence-associated secretory phenotype (SASP). The SASP is the major mediator of the paracrine effects of senescent cells in their tissue microenvironment and...

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PMID: 38654098
DOI: 10.1038/s41580-024-00727-x

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