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Article

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.

Genes & development - 15 Oct 2011

Chien Yuchen, Scuoppo Claudio, Wang Xiaowo, Fang Xueping, Balgley Brian, Bolden Jessica E, Premsrirut Prem, Luo Weijun, Chicas Agustin, Lee Cheng S, Kogan Scott C, Lowe Scott W

Abstract excerpt

Cellular senescence acts as a potent barrier to tumorigenesis and contributes to the anti-tumor activity of certain chemotherapeutic agents. Senescent cells undergo a stable cell cycle arrest controlled by RB and p53 and, in addition, display a senescence-associated secretory phenotype (SASP) inv...

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Identifiers

PMID: 21979375
DOI: 10.1101/gad.17276711
PMCID: PMC3205583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21979375-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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