Senescent cells and their secretory phenotype as targets for cancer therapy.

doi:10.1159/000343572

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Senescent cells and their secretory phenotype as targets for cancer therapy.

Interdisciplinary topics in gerontology - 1 Jan 2013

Velarde Michael C, Demaria Marco, Campisi Judith

Abstract excerpt

Cancer is a devastating disease that increases exponentially with age. Cancer arises from cells that proliferate in an unregulated manner, an attribute that is countered by cellular senescence. Cellular senescence is a potent tumor-suppressive process that halts the proliferation, essentially irreversibly, of cells at risk for malignant transformation. A number of anti-cancer drugs have emerged that induce tumor...

Topics

Aged
Anticarcinogenic Agents
Carcinogenesis
Cellular Senescence
Clinical Trials as Topic
Cytokinins
DNA Damage
Drug Evaluation, Preclinical
Genes, Tumor Suppressor
Humans
Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Targeted Therapy

Neoplasms

Peptide Hydrolases

Phenotype

Systems Biology

Tumor Microenvironment

Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 23503512
DOI: 10.1159/000343572
PMCID: PMC4167737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Senescent cells and their secretory phenotype as targets for cancer therapy.PMID 23503512Read ↗

Senescent Cells in Cancer Therapy: Friends or Foes?Semantic proximity Read ↗

Targeting senescent cells: approaches, opportunities, challengesSemantic proximity Read ↗

The Contribution of Physiological and Accelerated Aging to Cancer Progression Through Senescence-Induced InflammationSemantic proximity Read ↗

Senescent Cells in Cancer: Wanted or Unwanted CitizensSemantic proximity Read ↗

Cellular senescence: mechanisms and relevance to cancer and agingSemantic proximity Read ↗

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related DiseasesSemantic proximity Read ↗

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer TherapySemantic proximity Read ↗

The Jekyll and Hyde of Cellular Senescence in CancerSemantic proximity Read ↗

The senescence-associated secretory phenotype: the dark side of tumor suppression.Semantic proximity Read ↗

Cellular Senescence: The Sought or the Unwanted?Semantic proximity Read ↗

The dual role of cellular senescence in human tumor progression and therapySemantic proximity Read ↗

Senescence and tumor suppressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.