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Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges

20 Jun 2025

Abstract excerpt

Cellular senescence is a complex process that significantly contributes to the pathogenesis of various diseases, including cancer and neurodegenerative disorders. It is characterized by permanent cell cycle arrest and morphological changes, such as cell enlargement and a decrease in lamin B levels. As organisms age, a secretory phenotype known as the senescence-associated secretory phenotype (SASP) develops,...

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Cancer Research and Treatments
Genetics, Aging, and Longevity in Model Organisms
Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40643463
DOI: 10.3390/cells14130942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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