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Article

CDK4/6 inhibition induces a senescence-associated secretory phenotype via delayed NF-κB activation.

Life science alliance - 1 Sept 2026

Yeung Joanna Lan-Hing, Rendleman Justin, Anderson Westcott Lauren, Ou Arnold, Pressler Matthew, Pagane Nicole, Duba Irene, Hosuru Ria, Tumenbayar Bat-Ider, Risca Viviana I

Abstract excerpt

Cellular senescence consists of regulated phenotypes associated with permanent exit from the cell cycle in response to stressors such as genomic instability. The consequences of senescence go beyond individual cells because of the senescence-associated secretory phenotype (SASP), which can induce inflammation in neighboring cells. Some cancers respond to CDK4/6 inhibitors (CDK4/6i) with a senescence-like...

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Identifiers

PMID: 42425764
DOI: 10.26508/lsa.202603790
PMCID: PMC13351265

Genes

CDK4
ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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