Article

High-throughput single-cell DNA sequencing of AML tumors with droplet microfluidics

2017-10-13

Abstract excerpt

<h4>ABSTRACT</h4> To enable the characterization of genetic heterogeneity in tumor cell populations, we developed a novel microfluidic approach that barcodes amplified genomic DNA from thousands of individual cancer cells confined to droplets. The barcodes are then used to reassemble the genetic profiles of cells from next generation sequencing data. Using this approach, we sequenced longitudinally collected AML...

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Literature Corpus work: bb680d06-ce29-54e4-a161-a9dc092f8e5e
DOI: 10.1101/203158

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