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Article

Genome-wide segregation of single nucleotide and structural variants into single cancer cells.

BMC genomics - 25 Nov 2017

Easton John, Gonzalez-Pena Veronica, Yergeau Donald, Ma Xiaotu, Gawad Charles

Abstract excerpt

BACKGROUND: Single-cell genome sequencing provides high-resolution details of the clonal genomic modifications that occur during cancer initiation, progression, and ongoing evolution as patients undergo treatment. One limitation of current single-cell sequencing strategies is a suboptimal capacity to detect all classes of single-nucleotide and structural variants in the same cells. RESULTS: Here we present a new...

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Identifiers

PMID: 29178827
DOI: 10.1186/s12864-017-4286-1
PMCID: PMC5702214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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