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Single-Cell Analysis of Circulating Tumor Cells: Why Heterogeneity Matters

19 Oct 2019

Abstract excerpt

Unlike bulk-cell analysis, single-cell approaches have the advantage of assessing cellular heterogeneity that governs key aspects of tumor biology. Yet, their applications to circulating tumor cells (CTCs) are relatively limited, due mainly to the technical challenges resulting from extreme rarity of CTCs. Nevertheless, recent advances in microfluidics and immunoaffinity enrichment technologies along with...

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PMID: 31635038
DOI: 10.3390/cancers11101595

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