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Article

Self-digitization chip for single-cell genotyping of cancer-related mutations.

PloS one - 1 Jan 2018

Thompson Alison M, Smith Jordan L, Monroe Luke D, Kreutz Jason E, Schneider Thomas, Fujimoto Bryant S, Chiu Daniel T, Radich Jerald P, Paguirigan Amy L

Abstract excerpt

Cancer is a heterogeneous disease, and patient-level genetic assessments can guide therapy choice and impact prognosis. However, little is known about the impact of genetic variability within a tumor, intratumoral heterogeneity (ITH), on disease progression or outcome. Current approaches using bulk tumor specimens can suggest the presence of ITH, but only single-cell genetic methods have the resolution to...

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PMID: 29718986
DOI: 10.1371/journal.pone.0196801
PMCID: PMC5931502

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NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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