Article
Single-Cell Digital Microfluidic Mass Spectrometry Platform for Efficient and Multiplex Genotyping of Circulating Tumor Cells.
Analytical chemistry - 18 Jan 2022
Ruan Qingyu, Yang Jian, Zou Fenxiang, Chen Xiaofeng, Zhang Qianqian, Zhao Kaifeng, Lin Xiaoye, Zeng Xi, Yu Xiyuan, Wu Lingling, Lin Shuichao, Zhu Zhi, Yang Chaoyong
Abstract excerpt
Gene mutation profiling of heterogeneous circulating tumor cells (CTCs) offers comprehensive and real-time molecular information of tumors for targeted therapy guidance, but the lack of efficient and multiplex genotyping techniques for single-CTC analysis greatly hinders its development and clinical application. This paper reports a single-CTC mass spectrometry analysis method for efficient and multiplex mutation...
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