Article

Genome-wide Segregation of Single Nucleotide and Structural Variants into Single Cancer Cells

2017-03-16

Abstract excerpt

We present a new approach for determining comprehensive variant profiles of single cells using a microfluidic amplicon-based strategy. This method can be used to reconstruct the clonal architecture and mutational history of a malignancy using all classes and sizes of single nucleotide and structural variants, providing insights into the temporal changes in mutational classes and processes that led to the developme...

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Literature Corpus work: 497bbaf4-59e6-5157-8476-ab54280bffeb
DOI: 10.1101/117663

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