Article

Dissecting β-Cardiac Myosin and Cardiac Myosin-Binding Protein C Interactions using a Nanosurf Assay

2022-03-12

Abstract excerpt

<h4>ABSTRACT</h4> Cardiac myosin-binding protein C (cMyBP-C) regulates cardiac contractility by slowing shortening velocity and sensitizing the thin filament to calcium. cMyBP-C has been shown to interact with the proximal myosin S2 tail and the thin filament. However, the relative contribution of these interactions to the collective modulation of actomyosin ensemble function remains unclear. Hence, we developed...

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Literature Corpus work: bb3c0741-fe2a-5c7e-83e8-be363edb1f99
DOI: 10.1101/2022.03.11.483820

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