Article

The E525K β-Myosin Mutation Causes Hypocontractility in Cardiomyocytes Without Altering Loaded Crossbridge Cycling

2026-06-22

Abstract excerpt

The cardiac β-myosin (MYH7) mutation E525K was identified in 2012 in a patient with dilated cardiomyopathy (DCM). Work using engineered constructs has shown that this mutation stabilizes the interacting heads motif (IHM) of myosin and increases the ATPase activity of mutant motor S1 heads. However, no measurements have been made in myofilaments or cardiomyocytes to determine its effect on contractile function. Her...

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Literature Corpus work: fb9a4772-3aef-5abb-98eb-edd7bcdf847e
DOI: 10.64898/2026.06.18.733270

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