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Article

Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations.

Journal of molecular and cellular cardiology - 1 Jan 2024

Wong Fiona L, Bunch Thomas A, Lepak Victoria C, Steedman Allison L, Colson Brett A

Abstract excerpt

N-terminal cardiac myosin-binding protein C (cMyBP-C) domains (C0-C2) bind to thick (myosin) and thin (actin) filaments to coordinate contraction and relaxation of the heart. These interactions are regulated by phosphorylation of the M-domain situated between domains C1 and C2. In cardiomyopathies and heart failure, phosphorylation of cMyBP-C is significantly altered. We aimed to investigate how cMyBP-C interacts...

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Identifiers

PMID: 38008210
DOI: 10.1016/j.yjmcc.2023.11.010
PMCID: PMC10872421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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