Article

Single-molecule analysis sheds light on cardiac myosin dysfunction due to hypertrophic cardiomyopathy mutation A57D in ventricular myosin light chain-1 (MLC1v)

2026-03-09

Abstract excerpt

Ventricular myosin light chain-1 (MLC1v) is a key structural and function-modulating component of the β-cardiac myosin (βM-II) motor complex. Single-point mutations in MLC1v are linked to severe forms of hypertrophic cardiomyopathy (HCM) and sudden cardiac death (SCD) at a young age. However, the molecular mechanisms underlying the motor dysfunction responsible for HCM phenotype development are not fully understoo...

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Literature Corpus work: 9405175b-0469-558f-b230-14fb00f3c1e3
DOI: 10.64898/2026.03.06.710098

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Single-molecule analysis sheds light on cardiac myosin dysfunction due to hypertrophic cardiomyopathy mutation A57D in ventricular myosin light chain-1 (MLC1v)DOI 10.64898/2026.03.06.710098Read

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