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Article

Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy.

ACS nano - 22 Jun 2021

Suay-Corredera Carmen, Pricolo Maria Rosaria, Velázquez-Carreras Diana, Pathak Divya, Nandwani Neha, Pimenta-Lopes Carolina, Sánchez-Ortiz David, Urrutia-Irazabal Iñigo, Vilches Silvia, Dominguez Fernando, Frisso Giulia, Monserrat Lorenzo, García-Pavía Pablo, de Sancho David, Spudich James A, Ruppel Kathleen M, Herrero-Galán Elías, Alegre-Cebollada Jorge

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a disease of the myocardium caused by mutations in sarcomeric proteins with mechanical roles, such as the molecular motor myosin. Around half of the HCM-causing genetic variants target contraction modulator cardiac myosin-binding protein C (cMyBP-C), although the underlying pathogenic mechanisms remain unclear since many of these mutations cause no alterations in protein...

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Identifiers

PMID: 34060810
DOI: 10.1021/acsnano.1c02242
PMCID: PMC8514129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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