Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.

doi:10.1073/pnas.2025030118

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Article

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 2021

Vander Roest Alison Schroer, Liu Chao, Morck Makenna M, Kooiker Kristina Bezold, Jung Gwanghyun, Song Dan, Dawood Aminah, Jhingran Arnav, Pardon Gaspard, Ranjbarvaziri Sara, Fajardo Giovanni, Zhao Mingming, Campbell Kenneth S, Pruitt Beth L, Spudich James A, Ruppel Kathleen M, Bernstein Daniel

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, associated with over 1,000 mutations, many in β-cardiac myosin (MYH7). Molecular studies of myosin with different HCM mutations have revealed a diversity of effects on ATPase and load-sensitive rate of detachment from actin. It has been difficult to predict how such diverse molecular effects combine to influence forces at the...

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Identifiers

PMID: 34117120
DOI: 10.1073/pnas.2025030118
PMCID: PMC8214707

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Source receipt: pubmed, retrieved 7 Sept 2026.

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