Article

Nanomechanical phenotypes in cMyBP-C mutants that cause hypertrophic cardiomyopathy

2020-09-19

Abstract excerpt

<h4>ABSTRACT</h4> Hypertrophic cardiomyopathy (HCM) is a disease of the myocardium caused by mutations in sarcomeric proteins with mechanical roles, such as the molecular motor myosin. Around half of the HCM-causing genetic variants target contraction modulator cardiac myosin-binding protein C (cMyBP-C), although the underlying pathogenic mechanisms remain unclear since many of these mutations cause no alteration...

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Literature Corpus work: 1b6d4fb8-3502-50fc-a071-cf3ed4fa5971
DOI: 10.1101/2020.09.19.304618

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