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Article

Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.

Cell reports - 12 May 2015

Aksel Tural, Choe Yu Elizabeth, Sutton Shirley, Ruppel Kathleen M, Spudich James A

Abstract excerpt

Cardiomyopathies due to mutations in human β-cardiac myosin are a significant cause of heart failure, sudden death, and arrhythmia. To understand the underlying molecular basis of changes in the contractile system's force production due to such mutations and search for potential drugs that restor...

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Identifiers

PMID: 25937279
DOI: 10.1016/j.celrep.2015.04.006
PMCID: PMC4431957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25937279-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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