Article

Non-coding autoimmune risk variant accelerates T peripheral helper cell development via ICOS

2022-12-16

Abstract excerpt

<h4>ABSTRACT</h4> Fine-mapping and functional studies implicate rs117701653, a common non-coding variant in the CD28/CTLA4/ICOS locus, as a contributor to risk for rheumatoid arthritis and type 1 diabetes. Using DNA pulldown, mass spectrometry, genome editing and eQTL analysis, we establish that the disease-associated allele reduces affinity for the inhibitory chromosomal regulator SMCHD1 to drive expression of...

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Literature Corpus work: bb3828ee-14c7-52ac-83b5-edeec7bb0f59
DOI: 10.1101/2022.12.16.520733

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