Article

Autoimmune non-coding variants perturb transcription factor–cofactor complex assembly linked to enhancer activity

2026-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Most autoimmune disease-associated variants lie in non-coding regions, but the molecular mechanisms linking these variants to gene regulation remain poorly understood. A major unresolved challenge is to determine how disease alleles alter transcription factor (TF) binding, cofactor (COF) recruitment, and enhancer activity at scale. Here, we used the CASCADE method to profile differential binding...

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Literature Corpus work: 84839cfc-e5ca-59cc-86de-b95145a62f29
DOI: 10.64898/2026.05.20.726379

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