Article
Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland.
Annals of the rheumatic diseases - 1 Sept 2025
Wiley Mandi M, Radziszewski Marcin, Khatri Bhuwan, Joachims Michelle L, Tessneer Kandice L, Stolarczyk Anna M, Yao Songyuan, Li James, Pritchett-Frazee Cherilyn, Johnston Audrey A, Rasmussen Astrid, Anaya Juan-Manuel, Aqrawi Lara A, Bae Sang-Cheol, Baecklund Eva, Björk Albin, Brun Johan G, Bucher Sara Magnusson, Dand Nick, Eloranta Maija-Leena, Engelke Fiona, Forsblad-d'Elia Helena, Fugmann Cecilia, Glenn Stuart B, Gong Chen, Gottenberg Jacques-Eric, Hammenfors Daniel, Imgenberg-Kreuz Juliana, Jensen Janicke Liaaen, Johnsen Svein Joar Auglænd, Jonsson Malin V, Kelly Jennifer A, Khanam Sharmily, Kim Kwangwoo, Kvarnström Marika, Mandl Thomas, Martín Javier, Morris David L, Nocturne Gaetane, Norheim Katrine Brække, Olsson Peter, Palm Øyvind, Pers Jacques-Olivier, Rhodus Nelson L, Sjöwall Christopher, Skarstein Kathrine, Taylor Kimberly E, Tombleson Phil, Thorlacius Gudny Ella, Venuturupalli Swamy R, Vital Edward M, Wallace Daniel J, Radfar Lida, Brennan Michael T, James Judith A, Scofield R Hal, Gaffney Patrick M, Criswell Lindsey A, Jonsson Roland, Appel Silke, Eriksson Per, Bowman Simon J, Omdal Roald, Rönnblom Lars, Warner Blake M, Rischmueller Maureen, Witte Torsten, Farris A Darise, Mariette Xavier, Shiboski Caroline H, Wahren-Herlenius Marie, Alarcón-Riquelme Marta E, Ng Wan-Fai, Sivils Kathy L, Guthridge Joel M, Adrianto Indra, Vyse Timothy J, Tsao Betty P, Nordmark Gunnel, Lessard Christopher J
Abstract excerpt
OBJECTIVES: Sjögren's disease (SjD) and systemic lupus erythematosus (SLE) share genetic risk at the DDX6-CXCR5 locus (11q23.3). Identifying and functionally characterising shared SNPs spanning this locus can provide new insights into common genetic mechanisms of autoimmunity. METHODS: Transdisease meta-analyses, fine-mapping, and bioinformatic analyses prioritised shared likely functional single nucleotide...
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