Article

InsulatorLeak, a mechanism-first pipeline for variant prioritization by predicted CTCF insulator disruption across seven autoimmune diseases

2026-04-10

Abstract excerpt

<title>Abstract</title> <p>Genome-wide association studies have mapped hundreds of autoimmune risk loci, yet fewer than 5% of associated variants have established causal mechanisms. CTCF-bound insulators partition the genome into regulatory domains. When disrupted, enhancers can activate genes they normally do not regulate, a phenomenon termed insulator leakage that has been implicated in malignancy and may contr...

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Literature Corpus work: 98fc4b71-9aa2-5d01-80a4-b835a785ae91
DOI: 10.21203/rs.3.rs-9368949/v1

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