Article
The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.
Genes and immunity - 1 Mar 2009
Haimila K, Einarsdottir E, de Kauwe A, Koskinen L L E, Pan-Hammarström Q, Kaartinen T, Kurppa K, Ziberna F, Not T, Vatta S, Ventura A, Korponay-Szabo I R, Adány R, Pocsai Z, Széles G, Dukes E, Kaukinen K, Mäki M, Koskinen S, Partanen J, Hammarström L, Saavalainen P
Abstract excerpt
IgA deficiency (IgAD) and common variable immunodeficiency (CVID) often co-occur in families, associating with chronic inflammatory diseases such as celiac disease (CD). ICOS (inducible co-stimulator) and CTLA4 (cytotoxic T-lymphocyte-associated protein-4) may be important in both disorders, as ICOS is necessary for Ig class-switching and CTLA4 negatively regulates T-cell activation. Linkage and association of CD...
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