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Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines

11 Nov 2022

Abstract excerpt

We combined functional genomics and human genetics to investigate processes that affect type 1 diabetes (T1D) risk by mediating beta cell survival in response to proinflammatory cytokines. We mapped 38,931 cytokine-responsive candidate cis-regulatory elements (cCREs) in beta cells using ATAC-seq and snATAC-seq and linked them to target genes using co-accessibility and HiChIP. Using a genome-wide CRISPR screen in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36778047
DOI: 10.1016/j.xgen.2022.100214

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