Back to search

Article

An allele-specific functional SNP associated with two autoimmune diseases modulates <i>IRF5</i> expression by long-range chromatin loop formation

2019-01-29

Abstract excerpt

Both Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc) are autoimmune diseases sharing similar genetic backgrounds. Genome-wide association studies (GWASs) have constantly disclosed numerous genetic variants conferring to both disease risks at 7q32.1, but the functional mechanisms underlying them are still largely unknown. Through combining fine-mapping and functional epigenomic analyses, we prioriti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3952d5fd-47aa-5b38-a8b4-b72e69cb207a
DOI
10.1101/533661
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
An allele-specific functional SNP associated with two autoimmune diseases modulates <i>IRF5</i> expression by long-range chromatin loop formationDOI 10.1101/533661
An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long-Range Chromatin Loop FormationSemantic proximity
Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus.Semantic proximity
A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE)Semantic proximity
Noncoding Variants as Genetic Contributors to Autoimmune Disease Pathogenesis.Semantic proximity
CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects <i>IRF8</i> expression through cooperative lncRNA and DNA methylation machinerySemantic proximity
A Multilayered Post-Genome-Wide Association Study Analysis Pipeline Defines Functional Variants and Target Genes for Systemic Lupus Erythematosus.Semantic proximity
Human follicular helper T cell promoter connectomes reveal novel genes and regulatory elements at SLE GWAS lociSemantic proximity
High-throughput identification of functional regulatory SNPs in systemic lupus erythematosusSemantic proximity
STAT3-mediated allelic imbalance of novel genetic variant rs1047643 and B cell specific super-enhancer in association with systemic lupus erythematosusSemantic proximity
High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.Semantic proximity
Discovery and Functional Characterization of Two Regulatory Variants Underlying Lupus Susceptibility at 2p13.1.Semantic proximity
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.Semantic proximity
Select a neighboring publication to make it the new centre.