Article

Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest

2020-03-20

Abstract excerpt

<h4>SUMMARY</h4> Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions including chronic obstructive pulmonary disease (COPD). However, the influence of SOR on T cell protective immunity remains uncharacterized. Here we show the detrimental effect of hypoxia on mitochondrial biogenesis in activated CD8+ T cells. We find that low oxygen diminishes CD8+ T cell viral response in vivo . Usin...

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Literature Corpus work: bafdfe1b-3003-539e-befe-12f452af864e
DOI: 10.1101/2020.03.19.999201

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