Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation

Abstract excerpt

Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain. We show that moderate-grade fever temperatures (39°C) increased murine CD4 T cell metabolism, proliferation, and inflammatory effector activity while decreasing regulatory T cell suppressive capacity. However, heat-exposed T helper 1 (T H 1) cells selectively developed mitochondrial stress and DNA damage that activated...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Heat shock proteins research
• Share to Immune Response and Inflammation
• Share to Thermal Regulation in Medicine