<scp>H</scp>uman<scp> CD4</scp>^<scp>+</scp><scp> T </scp>cells maintain specific functions even under conditions of extremely restricted<scp> ATP</scp> production

Abstract excerpt

We investigated the energy-adaptive potential of human CD4(+) T cells under conditions of impaired oxidative phosphorylation (OXPHOS) and/or low glucose (inhibiting glycolysis). These cells often encounter these conditions when executing their functions in injured/inflamed tissues, even though T cells themselves require constant and adequate energy supply via ATP. We assessed two specific functions, cytokine...

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