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Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

23 Jun 2025

Abstract excerpt

Abstract Mitochondria are integral to the regulation of CD8 + T cell function, critically influencing processes such as activation, differentiation, and long‐term persistence during immune responses. Emerging evidence highlights the detrimental impact of mitochondrial dysfunction on CD8 + T cell activity, contributing to immune exhaustion and impairing both antitumor and antiviral immunity. This underscores the...

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PMID: 40546111
DOI: 10.1002/advs.202503095

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