Article

Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

2021-10-07

Abstract excerpt

Pathogenic mitochondrial (mt)DNA molecules can exhibit heteroplasmy in single cells and cause a range of clinical phenotypes, although their contribution to immunity is poorly understood. Here, in mice carrying heteroplasmic C5024T in mt-tRNA Ala – that impairs oxidative phosphorylation – we found a reduced mutation burden in peripheral T and B memory lymphocyte subsets, compared to their naïve counterparts. Furth...

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Literature Corpus work: 828b9b44-2924-5986-9f24-d83b02551ff4
DOI: 10.1101/2021.10.05.21264464

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