Article

Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respiration

2024-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Pro-inflammatory macrophage activation is a hallmark example of how mitochondria serve as signaling organelles. Upon classical macrophage activation, oxidative phosphorylation sharply decreases and mitochondria are repurposed to accumulate signals that amplify effector function. However, evidence is conflicting as to whether this collapse in respiration is essential or largely dispensable. Here...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 18e9efa5-de37-582c-b026-4e141a6eb2dd
DOI: 10.1101/2024.05.10.593451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pro-inflammatory macrophage activation does not require inhibition of mitochondrial respirationDOI 10.1101/2024.05.10.593451Read

Macrophage activation as an archetype of mitochondrial repurposing.Semantic proximity Read

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.Semantic proximity Read

A20 restriction of nitric oxide production restores macrophage bioenergetic balanceSemantic proximity Read

Mitochondrial Biogenesis: Regulation By Endogenous Gases During Inflammation and Organ StressSemantic proximity Read

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammationSemantic proximity Read

The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis.Semantic proximity Read

How Mitochondrial Metabolism Contributes to Macrophage Phenotype and Functions.Semantic proximity Read

Persistent endotoxin exposure in macrophages elicits an immunometabolic profile susceptible to NF-κB and p53 perturbationSemantic proximity Read

Dissecting Metabolic Landscape of Alveolar MacrophageSemantic proximity Read

Mitochondrial metabolism mediated macrophage polarization in chronic lung diseasesSemantic proximity Read

Idiopathic Pulmonary Fibrosis: Aging, Mitochondrial Dysfunction, and Cellular BioenergeticsSemantic proximity Read

A past and present overview of macrophage metabolism and functional outcomes.Semantic proximity Read