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AMPK is necessary for Treg functional adaptation to microenvironmental stress during malignancy and viral pneumonia

18 Mar 2025

Abstract excerpt

CD4+FOXP3+ Treg cells maintain self tolerance, suppress the immune response to cancer, and protect against tissue injury during acute inflammation. Treg cells require mitochondrial metabolism to function, but how Treg cells adapt their metabolic programs to optimize their function during an immune response occurring in a metabolically stressed microenvironment remains unclear. Here, we tested whether Treg cells...

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PMID: 40100289
DOI: 10.1172/jci179572

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