Article

HIF-1α induces glycolytic reprogramming in tissue-resident alveolar macrophages to promote survival during acute lung injury

2022-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Cellular metabolism is a critical regulator of macrophage effector function. Tissue-resident alveolar macrophages (TR-AMs) inhabit a unique niche marked by high oxygen and low glucose. We have recently shown that in contrast to bone marrow-derived macrophages (BMDMs), TR-AMs cannot utilize glycolysis and predominantly rely on mitochondrial function for their effector response. It is not known ho...

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Literature Corpus work: 5a7815fb-745f-5e13-b1b2-5ae3bb630c28
DOI: 10.1101/2022.02.28.482301

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