Article

Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection

2022-02-22

Abstract excerpt

Defects in mitochondrial oxidative phosphorylation (OXPHOS) have been reported in COVID-19 patients, but the timing and organs affected vary among reports. Here, we reveal the dynamics of COVID-19 through transcription profiles in nasopharyngeal and autopsy samples from patients and infected rodent models. While mitochondrial bioenergetics is repressed in the viral nasopharyngeal portal of entry, it is up regulate...

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Literature Corpus work: 13189b21-a8a0-575d-863b-1b35ff61715e
DOI: 10.1101/2022.02.19.481089

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