Article

Mitochondrial Bioenergetic Failure in SLE Immunocytes: Targeting Fitness for Therapy

2025-06-14

Abstract excerpt

<h4>Background</h4> Systemic Lupus Erythematosus (SLE) is characterized by dysregulated immune responses linked to immunometabolic perturbations. While mitochondrial dysfunction has been implicated in SLE, its cell-type-specific impact on immune subsets remains underexplored. <h4>Methods</h4> We repurposed existing RNA-seq data from SLE patient peripheral blood mononuclear cells, with a focus on nuclear-encoded...

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Literature Corpus work: b643ac66-1d17-55a5-9e2a-41b0132f298e
DOI: 10.1101/2025.06.10.658845

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