Article

Translation of secretory mRNAs must be restrained during early oncogenesis to permit hepatocellular carcinoma initiation

2024-02-06

Abstract excerpt

<title>Abstract</title> <p>Increased protein synthesis drives proliferation of established tumours. However, how mRNA translation contributes to early tumorigenesis remains unclear. Following oncogene activation, hepatocytes enter a senescent phase characterized by deposition of extracellular matrix (ECM) niches which promote subsequent progression to hepatocellular carcinoma (HCC). We demonstrate an inverse rela...

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Literature Corpus work: baf253aa-3d9e-5ee5-9bd1-187e105f440c
DOI: 10.21203/rs.3.rs-3891270/v1

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