Article

LARP1 integrates MYC and mTOR signaling to enable anabolic growth during tumor initiation

2025-12-05

Abstract excerpt

Tumor initiation requires the integration of oncogenic signals with environmental cues to enable anabolic growth. Among oncogenic drivers, MYC is central to tumorigenesis, with its deregulation observed in more than 60% of human cancers. Oncogenic MYC profoundly rewires transcription, enabling cells to bypass cell cycle checkpoints and resetting metabolism. A cornerstone of this rewiring is the up regulation of bi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a7be22e-4488-52a0-ad28-314b5e3ba56b
DOI: 10.64898/2025.12.05.689906

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LARP1 integrates MYC and mTOR signaling to enable anabolic growth during tumor initiationDOI 10.64898/2025.12.05.689906Read

Translation initiation: a critical signalling node in cancer.Semantic proximity Read

Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity.Semantic proximity Read

p53 induces transcriptional and translational programs to suppress cell proliferation and growthSemantic proximity Read

Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutationSemantic proximity Read

eIF4G2-dependent translation restrains pancreatic cancer progressionSemantic proximity Read

Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer.Semantic proximity Read

Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer.Semantic proximity Read

Translational control in cancer etiology.Semantic proximity Read

Cross-talk between protein synthesis, energy metabolism and autophagy in cancerSemantic proximity Read

The cancerous translation apparatus.Semantic proximity Read

Changes in the Transcriptome and Synthetic Lethal Dependencies Following <i>KRAS</i> Mutant Expression Reveal Profound Tissue-SpecificitySemantic proximity Read

The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in CancersSemantic proximity Read