Article

A localization screen reveals translation factories and widespread co-translational RNA targeting

2020-05-21

Abstract excerpt

<h4>Summary</h4> Local translation allows a spatial control of gene expression. Here, we performed a dual protein/mRNA localization screen, using smFISH on 523 human cell lines expressing GFP-tagged genes. A total of 32 mRNAs displayed specific cytoplasmic localizations, and we observed local translation at unexpected locations, including cytoplasmic protrusions, cell edges, endosomes, Golgi, the nuclear envelope...

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Literature Corpus work: c6901426-4515-5809-a26d-630a4163785d
DOI: 10.1101/2020.05.20.106989

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