Article
Translation initiation in cancer: a novel target for therapy.
Molecular cancer therapeutics - 1 Sept 2002
Meric Funda, Hunt Kelly K
Abstract excerpt
Translation initiation is regulated in response to nutrient availability and mitogenic stimulation and is coupled with cell cycle progression and cell growth. Several alterations in translational control occur in cancer. Variant mRNA sequences can alter the translational efficiency of individual mRNA molecules, which in turn play a role in cancer biology. Changes in the expression or availability of components of...
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