Article

Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway

2023-07-17

Abstract excerpt

<h4>Background & Aims</h4> Heterozygous inactivating mutations of Serine Threonine Kinase 11 (STK11)/Liver Kinase B1 (LKB1) are causative to the Peutz-Jeghers syndrome (PJS), a hereditary disease characterized by gastrointestinal hamartomatous polyposis and increased cancer susceptibility. While LKB1 loss-induced polyp formation has been ascribed to non-epithelial tissues, how LKB1 deficiency increases cancer ris...

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Literature Corpus work: f4cd8154-2d41-5bbc-b430-15657865d4ee
DOI: 10.1101/2023.07.17.548873

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