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Article

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.

Gastroenterology - 1 Mar 2018

Sharma Deepika, Malik Ankit, Guy Clifford S, Karki Rajendra, Vogel Peter, Kanneganti Thirumala-Devi

Abstract excerpt

BACKGROUND & AIMS: Inflammatory bowel diseases (IBD) increase risk for colorectal cancer. Mutations in the Mediterranean fever gene (MEFV or pyrin) are associated with hereditary autoinflammatory disease and severe IBD. Expression of MEFV, a sensor protein that the initiates assembly of the inflammasome complex, is increased in colon biopsies from patients with IBD. We investigated the role of pyrin in intestinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29203393
DOI: 10.1053/j.gastro.2017.11.276
PMCID: PMC5847456

Genes

MEFV
BMI1
MSI1
OLFM4
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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