Article

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

2020-03-11

Abstract excerpt

<h4>Summary</h4> The Human Silencing Hub (HUSH) complex epigenetically represses retroviruses, transposons and genes in vertebrates. HUSH therefore maintains genome integrity and is central in the interplay between intrinsic immunity, transposable elements and transcriptional regulation. Comprising three subunits – TASOR, MPP8 and Periphilin – HUSH regulates SETDB1-dependent deposition of the transcriptionally re...

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Literature Corpus work: a9dcfe33-6456-5e09-aa11-9de86ca4f8da
DOI: 10.1101/2020.03.09.974832

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